There is a Difference in Pain Relief...

Prescribing Information

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Dosage and Administration:

The usual adult dosage is two (2) TREZIX capsules orally every four (4) to six (6) hours, as needed.  Dosage should be adjusted according to the severity of the pain and the response of the patient.  No more than two (2) capsules should be taken in a 4-hour period.  No more than five (5) doses, or ten (10) capsules should be taken in a 24-hour period.  

The Road to Pain Relief Starts Here...

More Potency - Dihydrocodeine
  • More analgesic potency than Codeine (1)
  • Equal potency to 5 mg and 10 mg Hydrocodone products (1)
Avoids Complications - Acetaminophen
  • Under the recommended FDA 4,000 mg/day Acetaminophen levels 
Functional Pain Relief - Caffeine
  • Potentiates analgesic action of Acetaminophen by up to 40% (2)
  • Speeds onset of Acetaminophen (3)
  • Decreases drowsiness and fatigue commonly associated with opiates (3)

Hepatotoxicity:  Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death.  Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen containing product. The excessive intake of acetaminophen may be intentional to cause self-harm or unintentional as patients attempt to obtain more pain relief or unknowingly take other acetaminophen-containing products.  The risk of acute liver failure is higher in individuals with underlying liver disease and in individuals who ingest alcohol while taking acetaminophen.   

Instruct patients to look for acetaminophen or APAP on package labels and not to use more than one product that contains acetaminophen.  Instruct patients to seek medical attention immediately upon ingesting of more than 4000 milligrams of acetaminophen per day, even if they feel well.

Use caution in patients with hypersensitivity/anaphylaxis, in ambulatory patients, patients with respiratory depression, head injury, hypotensive effects to dihydrocodeine, and patients with dependence to opiates.  

Trezix is a Scheduled III drug.

1. Reisine T.k Pasternak G. Opioid analgesics and antagonist.  In: Gilman, AG, Hardman JG, Limbird LE, Molinoff PB Ruddon RW.  Goodman and Gilman's: The Pharmacological Basis of Therapeutics.  9th ed.  McGraw-Hill 1996: Chapter 23.
2. AGS Panel on Chronic Pain in Older Persons.  The management of chronic pain in older persons. JAGS. 1998; 46:635-651
3. Jick H. Effects of aspirin and acetaminophen in gastrointestinal hemorrhage.  Arch Intern Med. 1981; 141:316-321
4. Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A. Caffeine as an analgesic adjuvant. JAMA. 1984;251:1711-1718
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