Prescribing Information

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Dosage and Administration:

The usual adult dosage is two (2) TREZIX capsules orally every four (4) to six (6) hours, as needed.  Dosage should be adjusted according to the severity of the pain and the response of the patient.  No more than two (2) capsules should be taken in a 4-hour period.  No more than five (5) doses, or ten (10) capsules should be taken in a 24-hour period.  

The Power of Three

More Potency - Dihydrocodeine
  • More analgesic potency than Codeine (1)
  • Equal potency to 5 mg and 10 mg Hydrocodone products (1)
Avoids Complications - Acetaminophen
  • Under the recommended FDA 4,000 mg/day Acetaminophen levels 
Functional Pain Relief - Caffeine
  • Potentiates analgesic action of Acetaminophen by up to 40% (2)
  • Speeds onset of Acetaminophen (3)
  • Decreases drowsiness and fatigue commonly associated with opiates (3)

1. Reisine T.k Pasternak G. Opioid analgesics and antagonist.  In: Gilman, AG, Hardman JG, Limbird LE, Molinoff PB Ruddon RW.  Goodman and Gilman's: The Pharmacological Basis of Therapeutics.  9th ed.  McGraw-Hill 1996: Chapter 23.
2. AGS Panel on Chronic Pain in Older Persons.  The management of chronic pain in older persons. JAGS. 1998; 46:635-651
3. Jick H. Effects of aspirin and acetaminophen in gastrointestinal hemorrhage.  Arch Intern Med. 1981; 141:316-321
4. Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A. Caffeine as an analgesic adjuvant. JAMA. 1984;251:1711-1718
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