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Clinical Pharmacology: 

TREZIX™ capsules contain dihydrocodeine which is a semi-synthetic narcotic analgesic related to codeine, with multiple actions qualitatively similar to those of codeine; the most prominent of these involve the central nervous system and organs with smooth muscle components.  The principal action of therapeutic value is analgesia.  This combination product also contains acetaminophen, a non-optiate, non-salicylate analgesic and antipyretic.  This combination product contains caffeine as an analgesic adjuvant.   Caffeine is also a CNS and cardiovascular stimulant.

Indication and Usage:

TREZIX™ capsules are red capsules marked 'TREZIX' indicated for the relief of moderate to moderately severe pain.

Boxed Warning:

Death Related to Ultra-Rapid Metabolism of Codeine to Morphine

Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism.


Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death.  Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen containing product.

                                                                                 FDA APPROVED


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